Saturday, October 12, 2019

Alprazolam (Xanax): What are the facts?

Over the past year, there has been increasing media coverage about alprazolam (typically referred to by the brand name Xanax), highlighting what is being seen as a rise in the number of young people using it. Most of the media reports have described individual cases or reports from treatment services, and there has been little discussion of the research evidence or the actual data.
As with all media coverage which highlights potential changes in drug trends, there is a risk that the evidence isn’t clearly presented or even available, and that raising the profile of a particular drug can inadvertently merger interest from some drug users.
PHE has been looking into the available evidence, and this blog explains what we now know, what is currently being done, and what should be done in the future.

What is alprazolam?
Alprazolam is a medicine in the benzodiazepine family of drugs. Benzodiazepines are most commonly prescribed for the treatment of anxiety and insomnia, and they are also prescribed to control seizures caused by epilepsy.
The most frequently prescribed benzodiazepine in the UK is diazepam, known by the tradename Valium. In comparison, alprazolam is a faster acting medicine and is about 10 times stronger, meaning that it can rapidly cause feelings of sedation.
Like other benzodiazepines, alprazolam can work problems when taken without medical supervision. In the short term, its misuse can cause over-sedation, collapsing and overdose. Longer-term use can lead to physical dependence and severe withdrawal upon reducing or stopping use.
Furthermore, taking any benzodiazepine with alcohol and/or other drugs increases the risk of harm. This is particularly the case when benzodiazepines are mixed with other sedative drugs.
Alprazolam is not available from the NHS, but can be obtained on a private prescription in the UK. Illicit alprazolam, normally in the form of counterfeit Xanax tablets, can be bought from street level drug markets and is also available to purchase from illegal websites and social media apps.
What is being said about alprazolam (Xanax)?
There have been a growing number of personal stories reported in the media, often about young people who have developed problems with alprazolam (Xanax), as well as anecdotal reports that they are self-medicating for anxiety issues.
There have also been discussions around alprazolam in political circles. In January this year, the MP Bambos  Charalambous led the first debate in the House of Commons to discuss its misuse.
Sometimes, the use of alprazolam (Xanax) is portrayed in the media as a major epidemic among young people. There is currently no evidence of this, but, as we explain further down, there is some evidence that prevalence is increasing. It is important to understand that patterns of drug use change over time. Some drugs rapidly emerge but then their use commonly declines, other drugs persist and cause significant and sustained harm. It is currently too early to know which category alprazolam will fall into.